Plasma concentration-time profiles exhibit multiple peaks, suggesting enterohepatic recycling. The dialyzability of simvastatin and its metabolites in man is not known at present. Vytorin and placebo groups, respectively.
Upon rechallenge 2 months later, the patient developed pain in the contralateral arm overlying the biceps tendon. Following discontinuation of ezetimibe-simvastatin, pain resolved 2 weeks later. Inhibition of matrix metalloproteinases has been suggested as the contributing factor in the development of tendon rupture. Walshe, J. J. Renal failure associated with alternative medical therapies. Ren Fail. Child-Pugh score 5 to 6 compared to healthy subjects. The mean AUC values for total ezetimibe and ezetimibe increased approximately 3- to 4-fold and 5- to 6-fold, respectively, in patients with moderate Child-Pugh score 7 to 9 or severe hepatic impairment Child-Pugh score 10 to 15.
Ezetimibe is a white, crystalline powder that is freely to very soluble in ethanol, methanol, and acetone and practically insoluble in water. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
There are rare reports of congenital anomalies following intrauterine exposure to statins. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Fintelmann V. Antidyspeptic and lipid-lowering effects of artichoke leaf extract - results of clinical studies into the efficacy and tolerance of Hepar-SL forte involving 553 patients. Pedersen TR, Kjekshus J, Berg K, Haghfelt T, Faergeman O, Thorgeirsson G, Pyorala K, Miettinen T, Wilhelmsen L, Olsson AG, Wedel "Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study 4S.
Adzet T. Action of an artichoke extract against carbon tetrachloride-induced hepatotoxicity in rats. Mannarino, E. Artichoke juice improves endothelial function in hyperlipemia. Inegy tablets contain a sugar called lactose. In clinical studies in patients with AIS Studies 1 and 2 the incidence of intracranial hemorrhage, especially symptomatic intracranial hemorrhage, was higher in Activase-treated patients than in placebo patients. Schreiber VJ, Erb W, Wildgrube J, and Bohle E. Die fakale ausscheidung von gallensauren und lipiden des menschen bei normaler und medikamentos gesteigerter cholerese. About FAERS: The FDA Adverse Event Reporting System FAERS is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. Compare Vytorin Prices - GoodRx", "side_effects_page": "Vytorin Side Effects, Information and Pricing - GoodRx", "medicare_seo_page": "Vytorin Medicare Coverage and Co-Pay Details - GoodRx", "price_page": "Vytorin Prices and Vytorin Coupons - GoodRx", "info_page": "What is Vytorin? How should I take Vytorin? Vytorin in clinical studies, 3242 32% were 65 and older this included 844 8% who were 75 and older. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients but greater sensitivity of some older individuals cannot be ruled out. Acute Myocardial Infarction: Arrhythmias, AV block, cardiogenic shock, heart failure, cardiac arrest, recurrent ischemia, myocardial reinfarction, myocardial rupture, electromechanical dissociation, pericardial effusion, pericarditis, mitral regurgitation, cardiac tamponade, thromboembolism, pulmonary edema. These events may be life threatening and may lead to death. Take this medication by mouth with or without food as directed by your doctor, usually once daily in the evening. If you miss a dose, do not take an extra dose. Just resume your usual schedule.
All medicines may cause side effects, but many people have no, or minor, side effects. Feldmann R, Mainetti C, Saurat JH "Skin lesions due to treatment with simvastatin Zocor. This information should not be used to decide whether or not to take Vytorin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Vytorin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Vytorin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Vytorin. Compare prices and print coupons for Zetia Ezetimibe and other High Cholesterol drugs at CVS, Walgreens, and other pharmacies. Slight foaming is not unusual; let stand undisturbed for several minutes to allow large bubbles to dissipate. Inspect parenteral drug products for particulate matter and discoloration prior to administration whenever solution and container permit. HMG-CoA reductase. Inhibition of HMG-CoA reductase is a basis for an assay in pharmacokinetic studies of the β-hydroxyacid metabolites active inhibitors and, following base hydrolysis, active plus latent inhibitors total inhibitors in plasma following administration of simvastatin. The major active metabolites of simvastatin present in human plasma are the β-hydroxyacid of simvastatin and its 6'-hydroxy, 6'-hydroxymethyl, and 6'-exomethylene derivatives. Pedersen TR, Berg K, Cook TJ, Faergeman O, Haghfelt T, Kjekshus J, Miettinen T, Musliner TA, Olsson AG, Pyorala K, Thorgeirsso "Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the scandinavian simvastatin survival study. Aspirin and heparin have been administered concomitantly with and following infusions of Activase in the management of acute myocardial infarction and pulmonary embolism, but the concomitant administration of heparin and aspirin with and following infusions of Activase for the treatment of acute ischemic stroke during the first 24 hours after symptom onset has not been investigated. Because heparin, aspirin, or Activase may cause bleeding complications, carefully monitor for bleeding, especially at arterial puncture sites. Hemorrhage can occur 1 or more days after administration of Activase, while patients are still receiving anticoagulant therapy. Ezetimibe localizes at the brush border of the small intestine and inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. Muscle pain, tenderness and weakness myopathy. Muscle problems, including muscle breakdown, can be serious in some people and rarely cause kidney damage that can lead to death. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. clamoxin
Do not take other medicines unless they have been discussed with your doctor. It is also important to tell your doctor if you are taking coumarin anticoagulants drugs that prevent blood clots, such as warfarin. Vytorin contains ezetimibe, a selective inhibitor of intestinal cholesterol and related phytosterol absorption, and simvastatin, an HMG-CoA reductase inhibitor. Federman DG, Hussain F, Walters AB "Fatal rhabdomyolysis caused by lipid-lowering therapy. No animal carcinogenicity or fertility studies have been conducted with the combination of ezetimibe and simvastatin. The combination of ezetimibe with simvastatin did not show evidence of mutagenicity in vitro in a microbial mutagenicity Ames test with Salmonella typhimurium and Escherichia coli with or without metabolic activation. No evidence of clastogenicity was observed in vitro in a chromosomal aberration assay in human peripheral blood lymphocytes with ezetimibe and simvastatin with or without metabolic activation. orle.info lisinopril
HeFH were randomized to receive either ezetimibe coadministered with simvastatin or simvastatin monotherapy. Ezetimibe and simvastatin may also be used for purposes not listed in this medication guide. Muscle problems myopathy may occur with Vytorin. The risk of muscle problems may be greater in people who take higher doses of Vytorin, in people older than 64 years old, in females, or in people who have kidney problems or low thyroid function. It may also be greater in those who take it with certain other medicines eg, niacin especially in Chinese patients. Tell your doctor right away if you notice any unexplained muscle pain, tenderness, or weakness, especially if you also have a fever or general body discomfort. Tell your doctor if you have muscle problems that persist even after your doctor has told you to stop taking Vytorin. General Information about the safe and effective use of Vytorin. Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. Some received IV heparin on arrival to the emergency room prior to enrollment and randomization. Katznelson S "Effect of HMG-CoA reductase inhibitors on chronic allograft rejection. All patients recovered without sequelae. Do NOT take more than the recommended dose without checking with your doctor. Favorable Outcome is defined as recovery with minimal or no disability. Value greater than 1 indicates odds of recovery in favor of Activase treatment. p-Value for Odds Ratio is from Generalized Estimating Equations with logit link. Eating grapefruit or drinking grapefruit juice may increase the amount of Vytorin in your blood, which may increase your risk of serious side effects. The risk may be greater with large amounts of grapefruit or grapefruit juice. Avoid large amounts of grapefruit or grapefruit juice eg, more than 1 quart daily. Talk with your doctor or pharmacist if you have questions about including grapefruit or grapefruit juice in your diet while you are taking Vytorin. The initial volume of distribution approximates plasma volume. Statins work by reducing the cholesterol made in the liver while Zetia or ezetimibe work by blocking absorption of the cholesterol. Merck says it plans to submit the data to the Food and Drug Administration in mid-2015 to get approval to market the drug for reducing major cardiovascular events. Vytorin is administered in oral tablet form in the evenings once per day. Numerous other drugs may interact with Vytorin. online piracetam erfahrung
Cholesterol embolism has been reported rarely in patients treated with thrombolytic agents; the true incidence is unknown. Cholesterol embolism may present with livedo reticularis, "purple toe" syndrome, acute renal failure, gangrenous digits, hypertension, pancreatitis, myocardial infarction, cerebral infarction, spinal cord infarction, retinal artery occlusion, bowel infarction, or rhabdomyolysis and can be fatal. Hold the vial of Activase upside down, position it so that the center of the stopper is directly over the exposed piercing pin of the transfer device, and push the vial of Activase down so that the piercing pin is inserted through the center of the Activase vial stopper. Institute parenteral anticoagulation near the end of or immediately following the Activase infusion when the partial thromboplastin time or thrombin time returns to twice normal or less. Use with caution. May cause side effects to become worse. Includes two placebo-controlled combination studies in which the active ingredients equivalent to Vytorin were coadministered and two placebo-controlled studies in which Vytorin was administered. All doses. Fenofibrates may increase cholesterol excretion into the bile, leading to cholelithiasis. In the primary intent-to-treat analysis, 639 15. Multiple-dose studies of ezetimibe coadministered with statins in rats and rabbits during organogenesis result in higher ezetimibe and statin exposures. Reproductive findings occur at lower doses in coadministration therapy compared to monotherapy. Product Information. Zocor simvastatin. It is not known whether simvastatin is excreted in human milk. Because a small amount of another drug in this class is excreted in human milk and because of the potential for serious adverse reactions in nursing infants, women taking simvastatin should not nurse their infants. Lietti A. Choleretic and cholesterol lowering properties of artichoke extracts. Calan, Covera, Isoptin, Verelan. Serum cholesterol and triglycerides increase during normal pregnancy, and cholesterol or cholesterol derivatives are essential for fetal development. Because HMG-CoA reductase inhibitors statins such as simvastatin, decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, Vytorin may cause fetal harm when administered to a pregnant woman. Atherosclerosis is a chronic process and the discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia. There are no adequate and well-controlled studies of Vytorin use during pregnancy; however, in rare reports congenital anomalies were observed following intrauterine exposure to statins. In rat and rabbit animal reproduction studies, simvastatin revealed no evidence of teratogenicity. Vytorin should be administered to women of childbearing age only when such patients are highly unlikely to conceive.
TG, and non-HDL-C, and increases HDL-C in patients with hyperlipidemia. Traditionally, AA has been regarded as a stress-induced disease. Unfortunately that view persists today, even among some dermatologists, even though very little scientific evidence supports the view. NDC 66582-315-74 bottles of 500 If repackaged in blisters, then opaque or light-resistant blisters should be used. Violon, C. Belgian Chinese herb nephropathy: why? AMI to four thrombolytic regimens Study 3. Entry criteria included onset of chest pain within 6 hours of treatment and ST-segment elevation of ECG. Rarely, statins may cause or worsen diabetes. Talk to your doctor about the benefits and risks. The treatment effect of Vytorin on MVE was attenuated among patients on dialysis at baseline compared with those not on dialysis at baseline. The availability of the β-hydroxyacid to the systemic circulation following an oral dose of simvastatin was found to be less than 5% of the dose, consistent with extensive hepatic first-pass extraction. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Pharmacokinetic studies with another statin having a similar principal route of elimination to that of simvastatin have suggested that for a given dose level higher systemic exposure may be achieved in patients with severe renal impairment as measured by creatinine clearance. Products meeting necessary bioequivalence requirements. cost of ketorolac in canada
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. Vials THE 100 mg VIALS DO NOT CONTAIN VACUUM. Using the transfer device provided, reconstitute by adding the contents of the accompanying 100 mL vial of SWFI to the 100 mg vial of Activase. FILE - This 2004 file photo provided by Schering-Plough Corp. shows the cholesterol-lowering drug Vytorin. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ezetimibe and simvastatin combination in the elderly. However, elderly patients are more likely to have age-related muscle problems, which may require caution in patients receiving ezetimibe and simvastatin combination. This indicates that ezetimibe is neither an inhibitor nor an inducer of these cytochrome P450 isozymes, and it is unlikely that ezetimibe will affect the metabolism of drugs that are metabolized by these enzymes. Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke Cynara scolymus. Ann Allergy Asthma Immunol. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks. Approximately 78% and 11% of the administered radioactivity were recovered in the feces and urine, respectively, over a 10-day collection period. Ezetimibe was the major component in feces and accounted for 69% of the administered dose, while ezetimibe-glucuronide was the major component in urine and accounted for 9% of the administered dose. The comparative efficacy of these two regimens has not been evaluated. There have been postmarketing reports of increased INR in patients who had ezetimibe added to warfarin. Most of these patients were also on other medications. Each 50 mg Activase vial 29 million IU is packaged with diluent for reconstitution 50 mL Sterile Water for Injection, USP: NDC 50242-044-13. These results are consistent with ezetimibe being a potent cholesterol absorption inhibitor. Activase is indicated for the treatment of acute ischemic stroke. Severe allergic reactions rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness; breathing problems eg, persistent cough, shortness of breath; burning, numbness, or tingling; change in the amount of urine produced; confusion; decreased sexual ability; depression; difficult or painful urination; dizziness; fever, chills, or persistent sore throat; irregular heartbeat; joint pain; memory problems; muscle tenderness, pain, or weakness with or without fever and fatigue; red, swollen, blistered, or peeling skin; severe stomach or back pain with or without nausea or vomiting; swelling of the hands, ankles, or feet; symptoms of liver problems eg, dark urine, loss of appetite, pale stools, severe stomach pain, yellowing of the skin or eyes; trouble sleeping; unusual bruising or bleeding; unusual tiredness or weakness; vomiting. generic drontal guideline
AMI because it has been associated with an increase in intracranial bleeding. Taking Vytorin with certain other medicines may affect each other causing side effects. Vytorin may affect the way other medicines work, and other medicines may affect how Vytorin works. What happens if I overdose Vytorin? Some products that may interact with this drug include: "blood thinners" such as warfarin cyclosporine, danazol, gemfibrozil. The following adverse reactions have been identified during post-approval use of Activase. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. These reactions are frequent sequelae of the underlying disease, and the effect of Activase on the incidence of these events is unknown. AUC for total ezetimibe and ezetimibe increased approximately 4-fold compared to healthy subjects. Medicines should not be disposed of via wastewater or household waste. Invert the two vials so that the vial of Activase is on the bottom upright and the vial of SWFI is upside-down, allowing the SWFI to flow down through the transfer device. Take exactly as prescribed. Never take this medicine in larger amounts, or for longer than recommended by your doctor. Follow your doctor's dosing instructions very carefully. Taking too much of this medication may cause serious or life-threatening side effects. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Disclaimer: The indications, uses and warnings for individual medications outside the USA are determined by local regulatory bodies in each country or region. The Drugs. isoxsuprine
F. Protect the lyophilized material during extended storage from excessive exposure to light. Activase is for intravenous administration only. Extravasation of Activase infusion can cause ecchymosis or inflammation. If extravasation occurs, terminate the infusion at that IV site and apply local therapy. Studies to determine mutagenicity Ames test and chromosomal aberration assays in human lymphocytes were negative at all concentrations tested. Cytotoxicity, as reflected by a decrease in mitotic index, was evidenced only after prolonged exposure and only at the highest concentrations tested. When used together with higher doses of simvastatin, these medicines may increase your risk of muscle injury and could result in kidney problems. Barthel Index score of 95 or greater Modified Rankin Scale score of 1 or less Glasgow Outcome Scale score of 1 and NIHSS score of 1 or less. Vytorin needs to be initiated on an interacting drug that is contraindicated or is associated with a dose cap for simvastatin, that patient should be switched to an alternative statin or statin-based regimen with less potential for the drug-drug interaction. Patients should be advised of the increased risk of myopathy, including rhabdomyolysis, and to report promptly any unexplained muscle pain, tenderness or weakness. Weiland HH, Kindler K, Kranzl Ch, and et al. Uber den Einfluss von Cynarin auf Hyperlipidamien unter besonderer Berucksichtigung des Typs II Hypercholesterinamie. Open the package containing the transfer device by peeling the paper label off the package. Any other condition in which bleeding constitutes a significant hazard or would be particularly difficult to manage because of its location. US pharmacies. Save up to 80% instantly! Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. At first, one tablet with ezetimibe 10 milligrams mg plus simvastatin 10 mg or ezetimibe 10 mg plus simvastatin 20 mg once a day in the evening. Your doctor may adjust your dose as needed. However, the dose is usually not more than ezetimibe 10 mg plus simvastatin 40 mg per day. Keep out of the sight and reach of children. Take this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. The difference between the statin and combination therapy was modest, but significant. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition.
There may be new information. This information does not take the place of talking with your doctor about your medical condition or your treatment. If you have any questions about Vytorin, ask your doctor. Only your doctor can determine if Vytorin is right for you. Exclusivity is the sole marketing rights granted by the FDA to a manufacturer upon the approval of a drug and may run simultaneously with a patent. Exclusivity periods can run from 180 days to seven years depending upon the circumstance of the exclusivity grant. It may harm them, even if their signs of illness are the same as yours. The patient must also be a US resident. Belvue Road, Northolt, Middlesex, UB5 5QS. Coagulation tests and measures of fibrinolytic activity may be unreliable during Activase therapy, unless specific precautions are taken to prevent in vitro artifacts. When present in blood at pharmacologic concentrations, Activase remains active under in vitro conditions, which can result in degradation of fibrinogen in blood samples removed for analysis. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness, especially if you also have unusual tiredness or a fever. These could be symptoms of serious muscle problems, such as myopathy or immune-mediated necrotizing myopathy IMNM. Myopathy is more common when high doses of simvastatin 80 milligrams with ezetimibe 10 mg are used, but some people get myopathy with lower doses. PT was greater than 15 seconds or the activated partial thromboplastin time aPTT was elevated. Patients with prior aspirin use were included. Administration of anticoagulants and antiplatelet agents was prohibited for the first 24 hours following symptom onset. money order generic olanzapine shopping
Vytorin is effective in men and women with hyperlipidemia. Experience in non-Caucasians is limited and does not permit a precise estimate of the magnitude of the effects of Vytorin. Plasma cholesterol is derived from intestinal absorption and endogenous synthesis. Vytorin contains ezetimibe and simvastatin, two lipid-lowering compounds with complementary mechanisms of action. Vytorin reduces elevated total-C, LDL-C, Apo B, TG, and non-HDL-C, and increases HDL-C through dual inhibition of cholesterol absorption and synthesis. Inegy contains the active substances ezetimibe and simvastatin. Inegy is available in blister packs containing 28 tablets. F Activase may be used within 8 hours following reconstitution. Discard any unused solution after administration is complete. If your symptoms do not improve or if they become worse, check with your doctor. Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig. Therapeutic Equivalence-Related Terms, Pharmaceutical Equivalents generally will be coded AB if a study is submitted demonstrating bioequivalence. In addition to this medicine, your doctor may change your diet to one that is low in fat, sugar, and cholesterol. Carefully follow your doctor's orders about any special diet. Take Vytorin with or without food. The clinical significance of these findings is unclear. avana
It is unknown if this medication passes into breast milk. However, similar drugs pass into breast milk. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding. What happens if I miss a dose Vytorin? No clinically significant pharmacokinetic interaction was seen when ezetimibe was coadministered with simvastatin. No specific pharmacokinetic drug interaction studies with Vytorin have been conducted other than the following study with NIASPAN Niacin extended-release tablets. Does Vytorin 10-20 oral have side effects? Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit. You should keep on this cholesterol-lowering diet while taking Inegy.
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Vanpuijenbroek EP, Dubufvereijken PWG, Spooren PFMJ, Vandoormaal JJ "Possible increased risk of rhabdomyolysis during concomitant use of simvastatin and gemfibrozil. Store in the original package in order to protect from moisture and light. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use. Lipitor, Caduet fluvastatin Lescol lovastatin Mevacor, Altoprev, Advicor pravastatin Pravachol rosuvastatin Crestor or simvastatin Zocor, Simcor, Juvisync.
Pittler MH, Thompson CO, Ernst E. Artichoke leaf extract for treating hypercholesterolaemia. In this study, depending upon the scale, the favorable outcome of minimal or no disability occurred in at least 11 per 100 more patients treated with Activase than those receiving placebo. Study results demonstrated consistent functional and neurological improvement within all four stroke scales as indicated by median scores. In a study of 12 healthy volunteers, simvastatin at the 80-mg dose had no effect on the metabolism of the probe cytochrome P450 isoform 3A4 CYP3A4 substrates midazolam and erythromycin. This indicates that simvastatin is not an inhibitor of CYP3A4 and, therefore, is not expected to affect the plasma levels of other drugs metabolized by CYP3A4.
After oral administration, ezetimibe is absorbed and extensively conjugated to a pharmacologically active phenolic glucuronide ezetimibe-glucuronide. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Newman TB, Hulley SB "Carcinogenicity of lipid-lowering drugs. Schumacher YO, Zdebik A, Huonker M, Kreisel W "Sildenafil in HIV-related pulmonary hypertension. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.